Establishment and evaluation of a reversible two-kidney, one-clip renovascular hypertensive rat model
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چکیده
منابع مشابه
Establishment and evaluation of a reversible two-kidney, one-clip renovascular hypertensive rat model
The aim of the present study was to establish and evaluate a novel and reversible two-kidney, one-clip renovascular hypertensive rat model with a titanium vascular clip. A total of 40 male Sprague-Dawley rats were evenly and randomly divided into a sham-operated group, and 3, 7, 12 and 28D groups (namely removing the vascular clip in the renovascular hypertensive model after 3, 7, 12 and 28 day...
متن کاملCardiac output in conscious one-clip, two-kidney renovascular hypertensive rats.
Cardiac output and arterial pressure in the conscious state were observed in one-clip, two-kidney renovascular hypertensive rats with a chronically implanted electromagnetic flow probe and an arterial cannula. Normal Wistar rats were used as controls. At rest, cardiac output per body weight did not show any difference between hypertensive rats and normal controls. This kind of experimental hype...
متن کاملReversal of two-kidney one clip renovascular hypertension in the rat.
Attempted correction of two-kidney, one clip Goldblatt hypertension in the rat was carried out by three techniques; removal of the constricting clip, removal of the ischemic kidney, and converting enzyme blockade by oral captopril. Since duration of hypertension is said to be a critical factor, groups of rats were studied after short term (less than 6 weeks from clipping) and chronic (greater t...
متن کاملEffects of Low-dose Morphine on Nitric Oxide Concentration and Angiogenesis in Two-kidney One Clip Hypertensive Rats
Objective(s) We investigated the effects of low-dose morphine on nitric oxide (NO) and angiogenesis in two-kidney one clip hypertensive (2K1C) rats. Materials and Methods Male rats were divided into two groups: sham-clip operated and 2K1C. Each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. Blood pressure, heart rate, plasma renin activity (PRA), NO concentration an...
متن کاملEffect of clonidine on blood pressure in chronic one-kidney, one-clip and two-kidney, one-clip hypertensive rats.
Oral administration of clonidine lowered the high blood pressure in two-kidney, one-clip hypertensive rats in chronic stage (three to four months), but not in one-kidney, one-clip hypertensive rats. This reduction of blood pressure was well correlated with decrease in plasma renin concentration, but not with decrease in urinary noradrenaline excretion. These results suggest that the reduction o...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2017
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2017.4386